针刺对伊朗肥胖者的体重及抗热休克蛋白27、60、65、70的影响
【摘要】:
肥胖是21世纪最大的公共卫生挑战之一。肥胖会导致心血管疾病和癌症等多种疾病。肥胖的治疗方法有食疗、行为疗法、运动、药物治疗、手术和补充疗法等。补充疗法中,最近针灸治疗在伊朗越来越受关注而在这方面得研究文献很少。因此,本研究将针刺疗法的减肥效果及其机制,观察人体体重相关指数,生化指标及如抗热休克蛋白等指标。
本研究从马什哈德加埃姆沙医院营养门诊招募了18-60岁之间的男女超重(25≤BMI30)、肥胖(BMI≥30)受试者,针刺分为耳针组(n=190)和电体针组(n=178),排除患有心血管,内分泌疾病,服用药物,糖尿病,妊娠者。所有受试者都签署知情同意书,此项临床研究得到马什哈德医科大学伦理委员会理事会的批准。
耳针和电体针的受试者分别随机分为治疗组和安慰针灸对照组(安慰组采用非穴表浅浅针刺方法),针刺治疗45天,每周2次,治疗结束后再随访45天。所有受试者在临床观察期间均接受饮食减肥指导。人体测量指标包括体重指数(BMI),体重,身高,腰/臀比和身体脂肪百分比(通过生物阻抗分析仪)。生化指标包括空腹血糖、血脂和抗热休克蛋白。
所有人体测量指标、生化指标在治疗前及治疗后的45天和90天进行了评估。采用SPSS 16进行了统计分析。在治疗组和对照组,耳针和电体针受试者的体重、体重指数、腰/臀比都减小(p0.001)。不过,体重、体重指数和腰/臀比的减小百分率,治疗组比对照组显著(p0.001),而且在治疗后45天内,体重、体重指数并没有增加。耳针者的体重减少的百分率大于电体针者。
电体针组的血脂明显改善性(p0.001),但耳针组没有。耳针组和电体针组的抗热休克蛋白27,-60,-65,-70都减少P(p0.001),而且治疗组明显显着高于对照组(p0.001)
总而言之,耳针者和电体针者的体重、体重指数、腰围/臀围比及抗热休克蛋白都得以减少。不过,耳针者的体重和体重指数的减少较突出,电体针的血脂改善情况较突出。当然,针刺减肥应当由经验丰富的针灸师来完成。
【关键词】:耳压 体穴电针 体重指标 抗热休克蛋白
【学位授予单位】:北京中医药大学
【学位级别】:博士
【学位授予年份】:2010
【分类号】:R246
【目录】:
【学位授予单位】:北京中医药大学
【学位级别】:博士
【学位授予年份】:2010
【分类号】:R246
【目录】:
- Abstract8-10
- 中文摘要10-12
- 1.CHAPTER 1 Introduction12-33
- 1.1-What are overweight and obesity in Western and Chinese Medicine?12-13
- 1.2-Chinese Medicine and overweight and obesity13-16
- 1.2.1-Another Chinese classification14-15
- 1.2.2-Obesity due to excessive food intake15
- 1.2.3-Obesity due to Retention of Damp Heat15
- 1.2.4-Obesity due to Liver Stagnation15-16
- 1.2.5-Obesity due to Qi Deficiency of the Spleen and Lung16
- 1.2.6-Obesity due to Kidney Deficiency16
- 1.3-Clinical evaluation of obesity16-18
- 1.4-Epidemiology of overweight and obesity18-19
- 1.5-Etiology of overweight and obesity19-28
- 1.5.1-Genetics19-20
- 1.5.2-Critical periods for the development of overweight and obesity20-21
- 1.5.3-Metabolic Factors21-22
- 1.5.4-Macronutrient Balance22
- 1.5.5-Physiological factors and appetite Control22-23
- 1.5.6-Endocrine Causes23
- 1.5.7-Psychological factors23-25
- 1.5.8-Dietary factor25-26
- 1.5.9-Food choice eating patterns and food policy26-27
- 1.5.10-Physical Inactivity27-28
- 1.6-Treatment of obesity28-33
- 1.6.1-Dietary Treatment of obesity28-29
- 1.6.2-Physical activity and exercise29-31
- 1.6.3-Behavioral treatment31
- 1.6.4-Pharmacotherapy for obesity31-32
- 1.6.5-Surgical treatments32-33
- 1.6.6-Complementary Medicine33
- 2-CHAPTER 2 Literature review Complementary therapies for reducing body weight33-58
- 2.1-Dietary Supplements34
- 2.2-Chitosan34-35
- 2.3-Chromium Picolinate35
- 2.4-E.Sinica35-36
- 2.5-Garcinia Cambogia36
- 2.6-Glucomannan36-37
- 2.7-Guar Gum37
- 2.8-Plantago Psyllium37-38
- 2.9-Pyruvate38
- 2.10-Homeopathy38-39
- 2.11-Hypnotherapy39-40
- 2.12-What is Acupuncture?40-50
- 2.12.1-The treatment of obesity by Acupuncture41-47
- 2.12.1.1-Treatment of obesity by Acupuncture application42-45
- 2.12.1.2-Acupuncture application suppressing appetite45-47
- 2.12.2-Acupunctue,Beta Endorphin and lipolitic activity47-50
- 2.13-What is Heat shock Protein?50-58
- 2.13.1-Heat Shock Protein and Atherosclerosis51-52
- 2.13.3-Atherosclerosis and the role of inflammation52
- 2.13.4-Autoimmunity in atherogenesis52-53
- 2.13.553-55
- 2.13.6-Dyslipidaemia and Heat Shock Proteins55-58
- 3-CHAPTER 3 MATERIAL AND METHOD58-89
- 3.1-Aim58
- 3.2-Study Design58-65
- 3.3-Study Location65-66
- 3.4-Subjects66
- 3.5-Inclusion Criteria66
- 3.6-Exclusion Criteria66
- 3.7-Study Assumptions66-67
- 3.8-Estimation of sample size67-68
- 3.9-Statistical Analysis68
- 3.10-Questionnaire interview68-69
- 3.11-Anthropometric Assessment69-71
- 3.11.1-Waist/Hip Ratio (WHR)70
- 3.11.2-Body fat percentage (%BF)70
- 3.11.3-Blood pressure70-71
- 3.12-Blood samples71
- 3.13-Biochemical Assessments71-81
- 3.13.1-What is the method of Biochemistry analyze71-73
- 3.13.2-Fasting plasma glucose73
- 3.13.3-Triglycerides73-74
- 3.13.4-Cholesterol74
- 3.13.5-HDL-cholesterol74
- 3.13.6-LDL-cholesterol74-75
- 3.13.7-Serum high sensitivity CRP75
- 3.13.8-Measurement of Anti HSP75-81
- 3.13.8.1-What is an Enzyme-Linked Immunosorbent Assay (ELISA) method75-76
- 3.13.8.2-Plasma anti-HSPs titers by ELISA76-81
- 3.14-Dietary Advice81-82
- 3.15-How to do the plane82-83
- 3.16-Acpoint Prescription for losing weight83-89
- 3.16.1-Electro Body acupuncture83-86
- 3.16.2-Auricular Acupuncture or Ear acupuncture86-89
- 4-Chapter 4 Result89-112
- 4.1-Comparison of the weight pre and post treatment in real and sham groups92
- 4.2-Comparison of the BMI pre and post treatment in real and sham groups92-93
- 4.3-Comparison of the Waist Circumference pre and post treatment in real and sham groups93-94
- 4.4-Comparison of the Hip Circumference pre and post treatment in real and sham groups94
- 4.5-Comparison of the Triglyceride pre and post treatment in real and sham groups94-95
- 4.6-Comparison of the Total Cholesterol pre and post treatment in real and sham groups95-96
- 4.7-Comparison of the LDL-C pre and post treatment in real and sham groups96
- 4.8-Comparison of the hs-CRP pre and post treatment in real and control groups96-100
- 4.9-Comparison of the weight pre and post treatment in real and control groups100
- 4.10-Comparison of the BMI pre and post treatment in real and control groups100-101
- 4.11-Comparison of the Waist Circumference pre and post treatment in real and sham groups101-102
- 4.12-Comparison of the Hip Circumference pre and post treatment in real and sham groups102
- 4.13-Comparison of the Triglyceride pre and post treatment in real and sham groups102-103
- 4.14-Comparison of the Total Cholesterol pre and post treatment in real and shamGroups103-105
- 4.15-Compression of the Anti-HSPs pre and post treatment Between real and sham groups in Electro BodyAcuponctr105-109
- 4.16-Compression of the Anti-HSPs pre and post treatment Between real and sham groups in Ear Acupuncture109-112
- 5-Chapter 5 Discussion112-115
- 5.1-Effect of ear and electro body acupuncture on weight and BMI112-113
- 5.2-Effect of ear and electro body acupuncture on waist and hip circumstance113
- 5.3-Effect of ear and electro body acupuncture on lipid profile113-114
- 5.4-Effect of ear and electro body acupuncture on fasting blood sugar114
- 5.5-Effect of ear and electro body acupuncture on hS-CRP114
- 5.6-Effect of ear and electro body acupuncture on albumin and Cratenin114
- 5.7-Effect of ear and electro body acupuncture on Anti-HSPs114-115
- Limitation of the study115
- Conclusion115-116
- Suggestions116
- Acknowledgments116-117
- References117-126
- Appendix126-129
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