收藏本站
《吉林大学》 2012年
收藏 | 手机打开
二维码
手机客户端打开本文

A Clinicopathological Study and Ki67Expression of Glioma in Jilin Province, North East of China

Shabal Sapkota  
【摘要】:Background: After the establishment of relationship between angiogenesis and tumorgrowth by Folkman in1971, efforts are being made for treating cancer by targetingangiogenesis. Melanoma differentiation-associated-7(MDA-7) gene is a novel melanomadifferentiation associated gene that functions as a multi-modality anti-cancer agent.Manystudies have demonstrated it antiangiogenesis effect in different tumor models by variousroutes. Objective: The aim of this study to demonstrate its antiangiogenesis effect throughintramuscular injection of MDA-7gene with AAV in lymphoma mouse model byimmunohistochemistry study measured by expression of cd31. Methods: After successful establishment of lymphoma mouse model with singleintramuscular MDA-7gene therapy, after about7weeks cd31staining of lymphomatumor is examined for counting of microvessels density with control used as GFP vectors. Results: Stastical analysis of microvessel density staining demonstratedsignificantly(p=0.027) diminution in tumors from mice administrated AAV8-MDA7/IL-24,which showed an average microvessel count of only11.42+/-2.8than the control goupAAV-GFP with the value of15.25+/-4.8. Significance: This anti angiogenesis property of intramuscular AAV/MDA-7gene therapy in lymphoma mouse model provides a rationale for treatment of lymphoma infuture.
【学位授予单位】:吉林大学
【学位级别】:硕士
【学位授予年份】:2012
【分类号】:R739.4

手机知网App
【相似文献】
中国期刊全文数据库 前10条
1 葛林虎;彭思达;谭获;王春燕;于宝丹;郑丽霞;叶絮;;Inhibition of HOXB7 Gene Expression in Melanoma Cells by Small Interfering RNA[J];Chinese Journal of Cancer Research;2008年02期
2 徐晓玉;王淑美;陈伟海;陈刚;王友京;;Effects of Taohong Siwu Decoction Ⅱ in the Chick Chorioallantoic Membrane (CAM) Assay and on B16 Melanoma in Mice and Endothelial Cells ECV304 Proliferation[J];Journal of Traditional Chinese Medicine;2006年01期
3 ;Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapy[J];World Journal of Gastrointestinal Surgery;2010年04期
4 ;Antitumor effect of cytosine deaminase/5-fluorocytosine suicide gene therapy system mediated by Bifidobacterium infantis on melanoma[J];Acta Pharmacologica Sinica;2005年05期
5 ;IL-24/MDA-7 Suppressed the Transplantation Tumor in BALB/c Mice[J];Cellular & Molecular Immunology;2006年05期
6 ;Over-expression of hypoxia-inducible factor 1 alpha increases an-giogenesis of LNCaP cells[J];Journal of Nanjing Medical University;2007年04期
7 Andrea J. McKinney;Sheri L. Holmen;;Animal models of melanoma: a somatic cell gene delivery mouse model allows rapid evaluation of genes implicated in human melanoma[J];癌症;2011年03期
8 Jelena Grahovac;Tatjana Srdi?-Raji?;Juan Francisco Santiba?ez;Marijana Pavlovi?;Milena ?avi?;Sini?a Radulovi?;;Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib in vitro by altering cell bioenergetics[J];Cancer Biology & Medicine;2019年02期
9 Na Lv;Shuai Hao;Chonglin Luo;Alia Abukiwan;Ying Hao;Fei Gai;Weiwei Huang;Lingyun Huang;Xueyuan Xiao;Stefan B.Eichmüller;Dacheng He;;miR-137 inhibits melanoma cell proliferation through downregulation of GLO1[J];Science China(Life Sciences);2018年05期
10 Maria Teresa Valenti;Luca Dalle Carbonare;Monica Mottes;;Ectopic expression of the osteogenic master gene RUNX2 in melanoma[J];World Journal of Stem Cells;2018年07期
中国重要会议论文全文数据库 前10条
1 Han Jianqun;Zhang Xiaoyan;Xiu Ruijuan;;Tumor angiogenesis and tumor development in TLR2 knockout mice[A];中国微循环学会2014年全国学术会议大会汇编[C];2014年
2 阎锡蕴;;A novel anti-CD146 antibody inhibits tumor angiogenesis and tumor growth[A];第二届全国“跨学科蛋白质研究”学术讨论会论文集[C];2008年
3 ;Putative functional variants in the PSMB9 gene associated with risk of melanoma-a new finding from melanoma genome-wide association studies[A];2012年中国青年遗传学家论坛会议文集[C];2012年
4 陈龙;Huixin Yang;Yanbin Xiao;Xiaoxia Tang;Yuqian Li;Qiaoqiao Han;Junping Fu;Yuye Yang;Yuechun Zhu;;LncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells and inhibits tumor growth in vivo[A];第九届全国核糖核酸学术讨论会论文集[C];2016年
5 Lianmei zhao;lina Han;lei li;ming Ma;baoen Shan;;p-hydroxylcinnamaldehyde induces the differentiation of B16F1 melanoma cells via a GTP-Rho1-MAPKs pathway[A];第十届全国免疫学学术大会分会场交流报告(二)[C];2015年
6 James B.McCarthy;;RASSF1A IS A TUMOR SUPPRESSOR GENE IN MELANOMA THROUGH MEDIATING APOPTOSIS,CELL CYCLE PROGRESSION AND INHIBITION OF AKT/P70S6K/EIF4E SIGNAL PATHWAY[A];2010’全国肿瘤分子标志及应用学术研讨会暨第五届中国中青年肿瘤专家论坛论文汇编[C];2010年
7 Cyrill Johannes Gildas Emanuel Geraud;;Malignant melanoma 2010:an update[A];中华医学会第16次全国皮肤性病学术年会摘要集[C];2010年
8 Kevin Szulak;Gabriella Brum;David Calianese;Charles Best;Nicola Kouttab;AieXu;;Metastatic melanoma cells resist to oxidative stress due to active mTOR pathway and overproduction of melanin[A];中华医学会第十八次全国皮肤性病学术年会论文汇编[C];2012年
9 Matthew Weiland;Laila M.Poisson;David Nathanson;Henry W.Lim;;Circulating miRNAs could serve as biomarkers for melanoma[A];中华医学会第十八次全国皮肤性病学术年会论文汇编[C];2012年
10 Yongyong Tang;Wenyuan Duan;Jingxiang Zhao;Ziling Wang;;The inhibition of melanoma metastasis in C57BL/6 mice mediated by allo-reactive NK cell transfusion[A];中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议摘要集[C];2010年
中国博士学位论文全文数据库 前4条
1 夏玲芳;44例原发性阴道恶性黑色素瘤患者的回顾性临床病理分析[D];复旦大学;2012年
2 王东;混合多肽纳米疫苗治疗黑色素瘤的研究[D];华中科技大学;2016年
3 张凯;细丝蛋白A调控表皮生长因子受体活化在恶性黑色素瘤发病中的作用[D];河北医科大学;2014年
4 Ali Abdul Wahid Abdul Hussein Al Shawi;通过高通量筛选技术从中药材中发现抗黑色素瘤的新天然化合物[D];东北师范大学;2011年
中国硕士学位论文全文数据库 前10条
1 Shabal Sapkota;[D];吉林大学;2012年
2 Sulav Sapkota;[D];吉林大学;2012年
3 王超超;皮肤恶性黑色素瘤23例临床分析[D];浙江大学;2012年
4 田海英;147例恶性黑色素瘤临床病理及预后分析[D];大连医科大学;2014年
5 杜金;皮肤恶性黑色素瘤33例临床分析[D];新疆医科大学;2013年
6 郑中秋;消化道恶性黑色素瘤6例临床分析并文献复习[D];浙江大学;2010年
7 张静静;肛管直肠恶性黑色素瘤的诊治现状(2例病例报道并文献复习)[D];浙江大学;2015年
8 祝晓蕾;80例恶性黑色素瘤的临床特点及预后分析[D];大连医科大学;2012年
9 杨雯靖;肛管直肠恶性黑色素瘤38例临床分析[D];山西医科大学;2014年
10 李苗苗;MicroRNA-31在体外负调控白细胞介素-34表达[D];安徽医科大学;2018年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62791813
  • 010-62985026