收藏本站
收藏 | 手机打开
二维码
手机客户端打开本文

"Study of Acute Fatty Liver of Pregnancy"with Literature Review

SUCHI DWIVEDI  
【摘要】:Objectives:Our aim is to explore the clinical outcome of patients with acute fatty liver of pregnancy (AFLP), and evaluate the effect of early diagnosis and treatment. Methods:Seven patients who were diagnosed with acute fatty liver of pregnancy (AFLP) were retrospectively analyzed from February2005to January2013. The clinical records of the patients with AFLP were reviewed for clinical features, laboratory examinations, and maternal and perinatal prognosis. Routine laboratory evaluation revealed hyperbilirubinemia, moderately elevated liver transaminase, but negative serum hepatitis virus in each patient. For additional evidence,126cases of AFLP were reviewed retrospectively from original articles researched in A Medline-based English and Chinese Knowledge Infrastructure between the same periods. Results:The initial symptoms of all the7cases with AFLP were gastrointestinal symptoms; anorexia, nausea, vomiting, and progressive jaundice. Complication revealed with renal insufficiency in all patients. Hepatic failure and multiple organ dysfunction syndrome (MODS), hypoglycemia, disseminated intravascular coagulation (DIC) failure in4patients (57.1%), hemorrhagic shock, ARDS, hepatic encephalopathy were seen in3patients (42.8%) and changes of coagulation function of different degrees occurred in a short time when the disease was serious. There was only one case of maternal death (14.2%), three cases of perinatal death (30%) and one postnatal death (10%). Conclusion:AFLP occurs in late pregnancy, a rare clinical syndrome, occurred at about36weeks of gestation. Early diagnosis and prompt termination of pregnancy is the key of management, multidisciplinary collaboration, comprehensive treatment and effective prevention are helpful to improve prognosis of the cases with AFLP and perinatal death.


知网文化
【相似文献】
中国期刊全文数据库 前20条
1 ;Prognostic factors of fulminant hepatitis in pregnancy[J];Chinese Medical Journal;2005年20期
2 Kohei Tatsumi;Kazuo Ohashi;Sanae Taminishi;Soichi Takagi;Rie Utoh;Akira Yoshioka;Midori Shima;Teruo Okano;;Effects on coagulation factor production following primary hepatomitogen-induced direct hyperplasia[J];World Journal of Gastroenterology;2009年42期
3 ;Effects of Acute Normovolemic Hemodilution on Perioperative Coagulation and Fibrinolysis in Elderly Patients Undergoing Hepatic Carcinectomy[J];Chinese Medical Sciences Journal;2010年03期
4 ;Pregnant woman with fulminant hepatic failure caused by hepatitis B virus infection: A case report[J];World Journal of Gastroenterology;2004年15期
5 綦慧敏;李大新;张晶晶;刘力;张全斌;;Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity[J];Chinese Journal of Oceanology and Limnology;2008年02期
6 孙雨豪;陈晓琳;刘松;于华华;李荣锋;王雪芹;秦玉坤;李鹏程;;Preparation of low molecular weight Sargassum fusiforme polysaccharide and its anticoagulant activity[J];Journal of Oceanology and Limnology;2018年03期
7 Danuta Owczarek;Dorota Cibor;Mikolaj K Glowacki;Tomasz Rodacki;Tomasz Mach;;Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability[J];World Journal of Gastroenterology;2014年01期
8 梅恒;胡豫;王华芳;石威;邓君;郭涛;;Binding of EGF1 Domain Peptide in Coagulation Factor Ⅶ with Tissue Factor and Its Implications for the Triggering of Coagulation[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2010年01期
9 YEUNG Tok-fai,LAU Siu-wah,WONG Kin;An unusual case of hypereosinophilic syndrome and disseminated intravascular coagulation[J];Chinese Medical Journal;2005年18期
10 Stephan L Haas;Ralf Jesnowski;Michael Steiner;Frank Hummel;Jrg Ringel;Christine Burstein;Horst Nizze;Stefan Liebe;J Matthias Lhr;;Expression of tissue factor in pancreatic adenocarcinoma is associated with activation of coagulation[J];World Journal of Gastroenterology;2006年30期
11 Keigo Suetani;Chiaki Okuse;Kazunari Nakahara;Yosuke Michikawa;Yohei Noguchi;Midori Suzuki;Ryo Morita;Nozomi Sato;Masaki Kato;Fumio Itoh;;Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation[J];World Journal of Gastroenterology;2015年02期
12 Ben Clevenger;Susan V Mallett;;Transfusion and coagulation management in liver transplantation[J];World Journal of Gastroenterology;2014年20期
13 ;Fluids administration and coagulation characteristics in patients with different model for end-stage liver disease scores undergoing orthotopic liver transplantation[J];Chinese Medical Journal;2007年22期
14 Shweta Kurian;Jessica Macintyre;Muzammil Mushtaq;Caio Max Rocha-Lima;Yeon Ahn;;Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature[J];World Journal of Gastrointestinal Oncology;2012年07期
15 贺蓉;贺石林;;Factor Ⅺ as A Novel Target for Treatment of Thrombotic Disease[J];血栓与止血学;2011年06期
16 ;Disseminated intravascular coagulation scores as predictors for progressive hemorrhage and neurological prognosis following traumatic brain injury[J];Neural Regeneration Research;2011年02期
17 姜峰;余奇劲;;剖宫产手术弥散性血管内凝血的临床应对策略[J];医学与哲学(临床决策论坛版);2010年07期
18 Jana Naceradska;Katerina Novotna;Lenka Cermakova;Tomas Cajthaml;Martin Pivokonsky;;Investigating the coagulation of non-proteinaceous algal organic matter: Optimizing coagulation performance and identification of removal mechanisms[J];Journal of Environmental Sciences;2019年05期
19 Hongyan Sun;Ruyuan Jiao;Hui Xu;Guangyu An;Dongsheng Wang;;The influence of particle size and concentration combined with pH on coagulation mechanisms[J];Journal of Environmental Sciences;2019年08期
20 Zhongguo Zhang;Jun Wang;Dan Liu;Jiuyi Li;Xiaolin Wang;Boyu Song;Bing Yue;Kehui Zhao;Yun Song;;Hydrolysis of polyaluminum chloride prior to coagulation:Effects on coagulation behavior and implications for improving coagulation performance[J];Journal of Environmental Sciences;2017年07期
中国重要会议论文全文数据库 前10条
1 彭慧珍;许宝红;肖调义;;Molecular cloning,characterization and expression analysis of coagulation factor Ⅱ gene in grass carp(Ctenopharyngodon idella)[A];中国生理学会第24届全国会员代表大会暨生理学学术大会论文汇编[C];2014年
2 zhuhua cai;ge zheng;huamei cao;jie dai;sehnghua pan;qiang li;;Amniotic Fluid Embolism after Dinoprostone Application——Report of 2 cases and literature review[A];中华医学会第十次全国妇产科学术会议产科会场(产科学组、妊高症学组)论文汇编[C];2012年
3 Hongwei Li;Xiangcui Chen;Yujun Zhang;Qinglu Wang;;Changes in prothrombin time and platelet parameters of mice treated with vitamins C and E[A];中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议摘要集[C];2018年
4 Yixin Gao;Guoqiang Liang;Jun Ren;Huishu Liu;;Study on changes of coagulation factors activity in different periods of pregnancy[A];广东省生物物理学会2013年学术研讨会论文集[C];2013年
5 Xinjing Zhang;Xiaobin Feng;Peipei Song;Wei Tang;Qiang Li;Dalu Kong;Qiang Wu;TI Zhang;Tianqiang Song;;Diagnostic value of Des-γ-carboxy prothrombin in HBV-related hepatocellular carcinoma[A];第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议论文汇编[C];2014年
6 ;烧冲复合伤临床特点及救治策略改(英文)[A];第八届全国烧伤外科学年会论文汇编[C];2007年
7 Huajiang Wei;Chengyi Liu;Guoyong Wu;Ying Liu;Yuqing Zhang;Zhenguo Zhu;;Effects of haemodilution with 0.9% normal saline and 7.5% hypertonic saline on the optical properties of blood during coagulation[A];2015年中国生理学会运动生理学专业委员会会议暨“运动与心血管保护”学术研讨会论文摘要汇编[C];2015年
8 ;The role of Tissue Factor in embryonic development[A];2010·第一届斑马鱼学术研讨会论文摘要集[C];2010年
9 Norihiro Kokudo;;Des-gamma-carboxy prothrombin induces angiogenesis in human vascular endothelial cells[A];全国生化与分子药理学药物靶点研讨会论文摘要集[C];2008年
10 ;Selection for increased maternal body-volume does not differ between two Scincella lizards with different reproductive modes[A];第七届全国野生动物生态与资源保护学术研讨会论文摘要集[C];2011年
中国博士学位论文全文数据库 前2条
1 阮晓岚;血液病合并弥散性血管内凝血的诊断研究[D];华中科技大学;2014年
2 爱莎(Ccamara Aissata Kandet);[D];华中科技大学;2013年
中国硕士学位论文全文数据库 前7条
1 SUCHI DWIVEDI;[D];昆明医科大学;2013年
2 Maria Jose Gonzalez Mendez;SSA地区国家MMR的差异和影响因素分析[D];大连医科大学;2018年
3 MABINDRA SHRESTHA;[D];重庆医科大学;2017年
4 Augustine F.Tokpa;[D];华中科技大学;2012年
5 Deepak Bagale;[D];重庆医科大学;2014年
6 杨金转;基于视障者的网络课程页面无障碍设计研究[D];首都师范大学;2009年
7 郭玉凤;Prothrombin与PEBP1蛋白在胃癌组织中表达的意义[D];南华大学;2012年
中国知网广告投放
 快捷付款方式  订购知网充值卡  订购热线  帮助中心
  • 400-819-9993
  • 010-62982499
  • 010-62783978