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Intensive Insulin Therapy and Glycemic Control to Alleviate Acute Lung Injury in Cardiac Surgery under Cardiopulmonary Bypass

Gobin Veekash  
【摘要】:Aim and objective Insulin has been shown to have anti-inflammatory effects and also reducing the systemic inflammation during cardiopulmonary bypass (CPB), whereas hyperglycemia is known to increase the proinflammatory cytokines. In this study we aimed to assess the effect of Intensive Insulin Therapy(IIT) on cardiopulmonary bypass induced acute lung injury during cardiac surgeries. Methods Patients (n=40) undergoing elective cardiac surgery with median sternotomy under cardiopulmonary bypass were selected and were randomly divided into 2 groups, group C and group T. Group C (n=20) was the control group of the study and did not receive any intensive insulin therapy. Group IIT (n=20) was the Intensive Insulin Therapy with patients receiving insulin therapy throughout the operation according to the ALGIP protocol. Bio markers: High Mobility Group Box-1, Tumor Necrosis Factor-alpha, Neutrophil Elastase, and Myeloperoxidase levels were measured at different timing point. Results Bio markers levels were found to be lower in group IIT compared to group C. There was a significant decrease in the blood markers at two timing points(T2 and T3) in group IIT. High Mobility Group Box-1 had a biphasic increase in both groups but with values lower (p0.05) in group IIT at 10 mins(T2) and 2 hours(T3) after unclamping of aorta. The same tendency was observed with Tumor Necrosis Factor-alpha, Neutrophil Elastase, and Myeloperoxidase levels at same timing points but with a monophasic increase. Conclusion Our results show that Intensive Insulin Therapy has a beneficial effect on the suppression of some of the inflammatory markers associated with acute lung injury during cardiopulmonary bypass.

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1 郭惠明,Murali Chakravarthy,Vivek Jawali,K Jayaprakash,NV Shivananda;Awake off-pump coronary artery bypass surgery in 25 patients[J];South China Journal of Cardiology;2003年02期
2 张仁腾;;A perfusion mode of pulmonary artery during cardiopulmonary bypass[J];China Medical Abstracts(Surgery);2011年03期
3 Brad Walker;;Comparison of the Birds Point-New Madrid Floodway, Mississippi River and the Yolo Bypass, Sacramento River[J];Journal of Earth Science;2016年01期
4 Richard S Stubbs;Rohit Sarvepalli;;What makes a gastric bypass a good gastric bypass? Opinion and hypothesis[J];World Journal of Surgical Procedures;2014年02期
5 Shao-Wei Xiong;Dong-Yun Zhang;Xian-Ming Liu;Zeng Liu;Fang-Ting Zhang;;Comparison of different gastric bypass procedures in gastric carcinoma patients with type 2 diabetes mellitus[J];World Journal of Gastroenterology;2014年48期
6 Lan Xinzhen;;The Lose--Lose Game[J];Beijing Review;2017年12期
7 王鹏;;Bypass技术在动态取证中的应用[J];中国公共安全(学术版);2013年01期
8 毛斌;;The perioperative effects of metabolic syndrome on the off-pump coronary artery bypass[J];China Medical Abstracts(Surgery);2011年03期
9 Shivendra Singh;Ajay Kumar Sachdev;Adarsh Chaudhary;Anil Kumar Agarwal;;Palliative surgical bypass for unresectable periampullary carcinoma[J];Hepatobiliary & Pancreatic Diseases International;2008年03期
10 ;Effect of Cardiopulmonary Bypass on Pulmonary Function in Infants[J];上海交通大学学报(医学版);2006年08期
11 ;Resection of tracheal tumor under cardiopulmonary bypass: a case report[J];Chinese Medical Journal;2005年12期
12 石凤梧;Effect of epsilon-aminocaproic acid on fibrinolysis in patients undergoing open heart surgery with cardiopulmonary bypass[J];China Medical Abstracts;2005年03期
13 商宏伟;Effect of cardiopulmonary bypass on the gut mucosal barrier function in rat model[J];China Medical Abstracts;2005年03期
14 孙林;王永武;;Ventriculocoronary artery bypass(VCAB):a new approach to myocardial revascularization[J];China Medical Abstracts;2005年04期
15 程伟,肖颖彬,陈林,钟前进,王学锋;Effects of cardiopulmonary bypass on endothelial cell injury[J];Journal of Medical Colleges of PLA;2004年01期
16 Shahzad G Raja;Off-pump and on-pump coronary artery bypass surgery:time to move on[J];Chinese Medical Journal;2004年06期
17 ;Off-pump and on-pump coronary artery bypass surgery:reply to Dr. Shahzad G Raja[J];Chinese Medical Journal;2004年06期
18 Tanyal Oyos ,Rou-Yee Chenhsu ,Daniel A Katz ,Johnny E Brian ,Stephen C Rayhill;Vasopressor Agents without Volume Expansion as a Safe Alternative to Venovenous bypass during Cavaplasty Liver Transplantation[J];Journal of Nanjing Medical University;2004年05期
19 张诗海,姚尚龙;The Protective Effect of Propofol on Erythrocytes during Cardiopulmonary Bypass[J];华中科技大学学报(医学英德文版);2004年02期
20 苏肇伉,周成斌,张海波,祝忠群;Hormonal and metabolic responses of fetal lamb during cardiopulmonary bypass[J];Chinese Medical Journal;2003年08期
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3 Gui-You Liang;Han-Sheng Wu;Yi-min Niu;Jian Li;Qing-Yong Cai;Zheng-yu Gao;;Role of Insulin receptors in myocardial ischemia-reperfusion injury during cardiopulmonary bypass[A];2012贵州省医学会胸心血管外科年会论文集[C];2012年
4 ;The Application of Health Education in Peri-operation Period of Coronary Artery Bypass Grafting[A];中华护理学会健康教育研讨会暨讲习班论文集[C];2000年
5 ;Intimal hyperplasia thickness and blood flow in an axis-deviated arterial bypass[A];中国畜牧兽医学会2010年学术年会——第二届中国兽医临床大会论文集(上册)[C];2010年
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7 David A.Story;;Emergency cardiopulmonary bypass for prolonged cardiac arrest during hepatic resection[A];2006年浙江省麻醉学学术年会论文汇编[C];2006年
8 ;Comparative study of grafts flow between on-pump and off-pump coronary bypass surgery for patients with triple coronary artery disease[A];第八届华东六省一市胸心血管外科学术会议论文汇编[C];2005年
9 ZH Shi;M Zhang;S Liu;HH Zhang;YY Zhou;Y Ji;;Cognitive Outcome after Carotid or Vertebrobasilar Artery Stenting and EC-IC Bypass in Patients with Cerebral Ischemia[A];第四届全国痴呆与认知障碍学术研讨会及高级讲授班论文汇编[C];2015年
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